SELANK

COMPOUND OVERVIEW

Selank is a synthetic heptapeptide derived from the endogenous immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg), extended with the sequence Pro-Gly-Pro to enhance CNS penetration and stability. Developed in Russia, Selank has been studied extensively as an anxiolytic, nootropic, and neuroprotective compound with a unique mechanism that distinguishes it from conventional benzodiazepine-class research tools. It acts on the GABAergic system and simultaneously modulates BDNF, serotonin, dopamine, and the immune-neural interface, making it a multi-target research compound for studying anxiety, cognition, and neuroplasticity.

MECHANISM OF ACTION

Selank’s anxiolytic mechanism operates through GABAergic modulation without direct binding to benzodiazepine receptors — instead influencing GABA-A receptor sensitivity and endogenous GABA activity. It upregulates BDNF and stimulates serotonergic tone in prefrontal cortex and hippocampus, consistent with antidepressant pharmacology profiles. Selank also demonstrates enkephalinase inhibition, preserving endogenous enkephalins and contributing to stress-buffering effects. Its Tuftsin-derived backbone provides immunomodulatory activity, bridging neuroimmune research applications. Selank has demonstrated the ability to prevent cognitive decline under stress conditions in research models.

RESEARCH APPLICATIONS

• GABAergic system modulation research (non-benzodiazepine pathway)
• Anxiolytic and stress-response pharmacology studies
• BDNF-mediated neuroplasticity and cognitive research
• Neuroimmune modulation and Tuftsin receptor research
• Serotonergic and dopaminergic pathway interaction studies
• Nootropic and memory enhancement research
• Neuroprotective research under stress and oxidative challenge conditions

KEY RESEARCH FINDINGS

• Research demonstrates Selank reduces anxiety-like behavior in rat models without motor impairment — unlike benzodiazepine controls
• BDNF upregulation confirmed in hippocampal tissue following Selank administration in multiple studies
• Studies show Selank preserves cognitive performance under stress conditions, while vehicle controls show significant decline
• Immunomodulatory research confirms IL-6 regulation and natural killer cell activity modulation via Tuftsin-derived component
• Intranasal bioavailability research confirms CNS penetration within minutes of administration
• Serotonin transporter studies show Selank’s stabilizing effect on serotonergic transmission in prefrontal cortex

STORAGE & HANDLING

• Store lyophilized at -20°C; stable up to 24 months
• Reconstitute with sterile saline or bacteriostatic water; use within 14 days at 2–8°C
• Suitable for intranasal or subcutaneous research delivery routes
• Protect from light and heat
• Handle under sterile conditions with appropriate laboratory protocols

SPECIFICATIONS

DISCLAIMER: This compound is sold strictly for laboratory and research purposes only. It is not intended for human consumption, clinical use, or veterinary application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For use by licensed researchers and qualified professionals only. You must be 21 years of age or older to purchase.

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