COMPOUND OVERVIEW

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH) that acts as a non-selective agonist at melanocortin receptors, particularly MC3R and MC4R in the central nervous system. Unlike peripherally-acting compounds that target the vascular system, PT-141 operates centrally through the CNS to influence behavior and physiological responses. It was originally developed from Melanotan II and represents a significant research tool for studying melanocortin receptor pharmacology, particularly in the context of behavioral and neurological research models.

MECHANISM OF ACTION

PT-141 acts as an agonist at MC3R and MC4R receptors, which are expressed throughout the hypothalamus and limbic system. Activation of these receptors modulates dopaminergic and serotonergic pathways in the CNS. The compound’s mechanism is distinct from PDE5 inhibitors in that it operates at the CNS level rather than the vascular level. PT-141 also has affinity for MC1R (pigmentation) and MC5R, though its primary research interest lies in central melanocortin signaling and its behavioral correlates.

RESEARCH APPLICATIONS

• Central melanocortin receptor (MC3R/MC4R) pharmacology research
• CNS-mediated behavioral research in preclinical models
• Hypothalamic signaling and neuroendocrine pathway studies
• Melanocortin system modulation and its downstream CNS effects
• Comparison studies between peripheral vs. central mechanisms of action
• Dopaminergic and serotonergic pathway interaction research

KEY RESEARCH FINDINGS

• Research demonstrates PT-141’s high binding affinity for MC3R and MC4R receptors in CNS tissue
• Preclinical studies confirm centrally-mediated effects distinct from peripherally-acting compounds in the same therapeutic area
• Dose-response studies have characterized the receptor selectivity profile of PT-141 across all 5 melanocortin receptor subtypes
• Hypothalamic research has identified downstream dopaminergic pathway activation following MC4R agonism
• PT-141 has served as a lead compound in melanocortin receptor pharmacology and CNS research

STORAGE & HANDLING

• Store lyophilized at -20°C; stable for 24 months
• Reconstitute with bacteriostatic water; use within 28 days at 2–8°C
• Protect from light
• Handle in controlled research environment with appropriate safety protocols
• Follow institutional biosafety guidelines for peptide research

SPECIFICATIONS

DISCLAIMER: This compound is sold strictly for laboratory and research purposes only. It is not intended for human consumption, clinical use, or veterinary application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For use by licensed researchers and qualified professionals only. You must be 21 years of age or older to purchase.

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