COMPOUND OVERVIEW

CJC-1295 Without DAC (also known as Modified GRF 1-29 or Mod GRF 1-29) is a truncated and modified version of growth hormone-releasing hormone (GHRH). The ‘without DAC’ variant refers to the absence of the Drug Affinity Complex, resulting in a shorter half-life that more closely mimics the natural pulsatile secretion pattern of endogenous GHRH. This makes it particularly valuable in research protocols that aim to study physiological GH release patterns, as opposed to sustained GH elevation. CJC-1295 Without DAC has been widely studied for its role in GH axis activation, body composition modulation, and metabolic research.

MECHANISM OF ACTION

CJC-1295 Without DAC binds to GHRH receptors on pituitary somatotrophs, stimulating GH secretion in a pulsatile pattern. Its shorter active duration (approximately 30 minutes) mimics endogenous GHRH more closely than the DAC version. When combined with GHRPs such as Ipamorelin in research protocols, it produces a synergistic amplification of GH release. The compound works upstream of GH itself, preserving the natural feedback regulation via IGF-1 and somatostatin, making it a preferred tool for studying the GH axis without suppressing endogenous production.

RESEARCH APPLICATIONS

• GH axis stimulation and pulsatile GH release research
• Body composition and anabolic metabolism studies
• Anti-aging and longevity research models
• Synergistic GHRP combination protocols in research settings
• Sleep quality and recovery research (GH is predominantly released during slow-wave sleep)
• IGF-1 modulation and its downstream effects on tissue growth

KEY RESEARCH FINDINGS

• Research demonstrates robust GH secretion following CJC-1295 Without DAC administration, peaking within 30–60 minutes
• Combination studies with Ipamorelin show significantly amplified GH release versus either peptide alone
• Studies indicate preserved IGF-1 regulation when GH stimulation is pulsatile rather than continuous
• Research in aging models shows restoration of GH pulse amplitude toward youthful parameters
• Body composition studies indicate favorable shifts in lean mass and adipose tissue distribution with sustained protocols

STORAGE & HANDLING

• Store lyophilized at -20°C; stable up to 24 months
• Reconstitute with bacteriostatic water; refrigerate at 2–8°C; use within 28 days
• Do not freeze reconstituted solution
• Protect from UV light and heat
• Use sterile technique and appropriate research-grade equipment

SPECIFICATIONS

DISCLAIMER: This compound is sold strictly for laboratory and research purposes only. It is not intended for human consumption, clinical use, or veterinary application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For use by licensed researchers and qualified professionals only. You must be 21 years of age or older to purchase.

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