COMPOUND OVERVIEW

GHK-Cu (Copper Peptide GHK) is a naturally occurring tripeptide-copper complex (Glycine-Histidine-Lysine bound to copper) first identified in human plasma. It is one of the most extensively studied naturally occurring peptides in tissue regeneration and dermatological research. GHK-Cu plays a critical role in cellular renewal, wound healing, collagen synthesis, and anti-inflammatory signaling. Its unique copper-chelating structure allows it to act as a pleiotropic signaling molecule, influencing gene expression across hundreds of biological pathways. In dermatological research contexts, it has demonstrated remarkable skin-remodeling properties with an exceptional safety profile.

MECHANISM OF ACTION

GHK-Cu activates multiple tissue remodeling pathways simultaneously. It stimulates collagen and elastin synthesis, upregulates antioxidant enzymes (SOD, catalase), and promotes the production of growth factors including TGF-beta, FGF, and VEGF. At the genomic level, GHK-Cu has been shown to regulate over 4,000 genes in aged human skin fibroblasts — resetting their expression profile toward a younger state. It modulates the ubiquitin-proteasome system, promotes metalloproteinase expression for selective removal of damaged proteins, and enhances copper-dependent enzymatic activity throughout the extracellular matrix. Its anti-inflammatory effect is mediated through inhibition of TNF-alpha and NF-kB signaling.

RESEARCH APPLICATIONS

• Skin tissue remodeling, collagen, and elastin synthesis research
• Wound healing and tissue regeneration models
• Anti-aging and senescence reversal research at the cellular level
• Gene expression modulation studies in fibroblast models
• Anti-inflammatory and antioxidant pathway research
• Hair follicle regeneration and alopecia research
• Neurological protection and nerve regeneration studies

KEY RESEARCH FINDINGS

• Research demonstrates GHK-Cu stimulates collagen synthesis in human fibroblast cultures at nanomolar concentrations
• Gene expression studies show GHK-Cu modulates over 4,000 genes in aged fibroblasts, resetting profiles toward younger expression patterns
• Wound healing models show significantly accelerated closure rates with topical GHK-Cu application
• Anti-inflammatory studies confirm suppression of TNF-alpha production in macrophage cell cultures
• Hair follicle research demonstrates enlargement of follicles and stimulation of keratinocyte proliferation
• Antioxidant research shows upregulation of SOD and catalase gene expression in treated cell cultures

STORAGE & HANDLING

• Store lyophilized powder at -20°C; stable up to 24 months
• Reconstitute with bacteriostatic water or sterile saline for injection research; use within 28 days at 2–8°C
• For topical research applications, dissolve in appropriate carrier (e.g., propylene glycol/water mixture)
• Protect from light — copper peptides are light-sensitive
• Blue-green color is normal and indicates intact copper chelation

SPECIFICATIONS

DISCLAIMER: This compound is sold strictly for laboratory and research purposes only. It is not intended for human consumption, clinical use, or veterinary application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For use by licensed researchers and qualified professionals only. You must be 21 years of age or older to purchase.

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