NAD+

COMPOUND OVERVIEW

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in all living cells, serving as a fundamental electron carrier in metabolic redox reactions and a substrate for a wide class of regulatory enzymes including sirtuins (SIRTs) and PARPs. NAD+ levels decline significantly with age in most tissues, and this decline has been implicated as a central driver of metabolic dysfunction, mitochondrial deterioration, DNA repair deficits, and accelerated aging. The NAD+ provided by US Amino Peptides is produced via biofermentation, ensuring high purity and biological compatibility for research applications requiring direct coenzyme administration.

MECHANISM OF ACTION

NAD+ participates in over 500 enzymatic reactions. As a redox cofactor, it shuttles electrons in glycolysis, the TCA cycle, and the electron transport chain, driving ATP synthesis. As a signaling molecule, it is consumed by sirtuins (SIRT1–7) in deacylation reactions that regulate gene expression, mitochondrial biogenesis, and stress responses. PARPs (poly-ADP-ribose polymerases) consume NAD+ in DNA damage repair. CD38 and CD157 use NAD+ for calcium signaling. The research interest in NAD+ centers on restoring its declining levels in aging tissues and studying the downstream effects on metabolic health, longevity pathways, and cellular resilience.

RESEARCH APPLICATIONS

• Aging and longevity research — NAD+ decline and restoration models
• Sirtuin pathway activation and epigenetic regulation studies
• Mitochondrial biogenesis and energetics research
• DNA repair pathway modulation (PARP-mediated)
• Metabolic syndrome, insulin resistance, and obesity research
• Neurodegenerative disease models and neuroprotection research
• Exercise recovery and muscle energetics research

KEY RESEARCH FINDINGS

• Research demonstrates age-related NAD+ decline of 40–60% in metabolically active tissues including liver, muscle, and brain
• NAD+ supplementation in aged mouse models restores mitochondrial function and improves multiple markers of metabolic health
• Studies confirm sirtuin activation downstream of NAD+ restoration, with measurable epigenetic and metabolic effects
• Research in neurological models shows NAD+ repletion reduces neuroinflammation and improves neuronal survival
• PARP inhibition studies demonstrate NAD+ restoration accelerates DNA damage repair in cellular models
• Human and animal research indicates intravenous NAD+ administration produces rapid plasma NAD+ elevation compared to oral precursors

STORAGE & HANDLING

• Store lyophilized or liquid formulation at -20°C; protect from freeze-thaw cycling
• Once diluted for research use, use within 24 hours for best stability
• NAD+ is sensitive to light and oxidation — keep sealed and protected
• Use in research protocols appropriate for the intended delivery route
• Biofermented NAD+ is the highest purity form — handle accordingly

SPECIFICATIONS

DISCLAIMER: This compound is sold strictly for laboratory and research purposes only. It is not intended for human consumption, clinical use, or veterinary application. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. For use by licensed researchers and qualified professionals only. You must be 21 years of age or older to purchase.

usaminopeptides.com · For Researcher Inquiries Contact: info@usaminopeptides.com